Multidisciplinary research at the crossroads of psychology, physiology, and neurobiology.

Because the map is not the territory


Building bridges

Practices may be changing but the bulk of research still features little overlap between disciplines. Discoveries are made when translational and crosscutting approaches are applied into complex brain/body systems and functions. Bridging the gaps—where they exist—across the divide is one way to advance our collective understanding of who we are and human behaviour, and informing the design of inclusive and context relevant interventions and solutions.

Redrawing boundaries

Edging beyond established frontiers to investigate underexplored areas of translational neuroscience where psychology, neurobiology, physiology, global health and the computational sciences convene.

Crossing borders (areas of interest)

Stress, trauma, resilience and associations with emotion and interoceptive processing and regulation, metacognition and social behaviour. ⋆ Neurobiological and biomedical interventions for stress management, raising cognitive resilience, and better mental health outcomes in crisis, extreme, confined, and isolated settings. * Pain/pleasure axis + metacognition. ⋆ Characterizing neurobiology and brain activity of select altered states of consciousness.⋆

Detail of nerve cells from canine olfactory bulb, published in Sulla fina anatomia degli organi centrali del sistema nervoso (1885) by Camillo Golgi. Source.

Charted expanses (concluded studies)

The study, Travel Far Enough, Meet Yourself: Subjective Interoception, Emotion Regulation, and the Psychedelic Experience—Implications for Crisis Management in Middle Adulthood, investigated if certain experiences in midlife are associated with an ability to better manage episodes of crisis/stress and prompt general improvements in mental health and well-being. Middle adulthood (~ ages 35 to 60/65) is full of complex, overlapping, and compounded chronic and/or concurrent stressors that can decrease interoceptive tone (Infurna et al., 2020), dampen cognitive coping mechanisms like resilience (Kabat-Zinn, 2013; Lutz et al., 2016), and increase negative emotional affect to cause maladaptive thoughts and behaviours (Aldwin, 2021; Daly & Robinson, 2021; George et al., 2021; Ong et al., 2009; Wickrama et al., 2021). The rise in negative trends in high-income countries—from death by suicide amongst White, middle-aged men in the United States (Hu et al., 2008; Infurna et al., 2020) to ‘diseases of despair’ like drug and alcohol addiction (Berkovitch et al., 2021; George et al., 2021), depression and anxiety (Berkovitch et al., 2021; Blanchflower, 2020; Hendricks et al., 2015; Moreton et al., 2020)—challenge conventional ideas that well-being is at its apex in middle adulthood (Arnett, 2018; Galambos et al., 2020).

A broad methodological approach was used to fill gaps in knowledge regarding the cause and management of crisis/stress in middle adulthood. Secondary investigations investigated if a higher prevalence of maladaptive traits is associated with an increase in crisis episodes in middle adulthood and if positively perceived psychedelic experience(s) in midlife are associated with a decrease in the incidence and/or intensity of crisis states and related emotive/interoceptive loads.

Results? In short: Almost all respondents stated they were currently in crisis or had experienced one, with most crisis episodes taking place between the ages of 41 to 50 with multiple existential and physical drivers as causes. Many participants experienced changes to their interoceptive and emotive capacities. Psychedelic experiences had marginal impact on crisis management for a small number of participants.

Nerve cell detail (1900) by Santiago Ramón y Cajal. Source.

Explorations (research in progress and on the horizon)

Research collaborator on projects affiliated with labs at Massachusetts General Hospital and Harvard Medical School: Investigating cognitive behaviour, brain activity, and physiology of high-performing individuals in various ICE environments. * Interpersonal relationships and problem solving in ICE settings. * PTSD and stress in emergency responder (firefighter) populations. * Diet, psychophysiology and gut microbiome in genetic isolate populations. * Operational performance and psychoneuroimmunology in partial gravity. * Associations between interoceptive processing and emotion regulation in unique populations functioning in extreme, confined, and isolated environments to affect mental health and behavioural outcomes.

“The brain is a world consisting of a number of unexplored continents and great stretches of unknown territory.”

-Santiago Ramón y Cajal